依布硒抑制劑Ebselen?is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity.?Ebselen?acts as a?glutathione?peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including?nitric oxide?synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC),?NADPH?oxidase and gastric H+/K+-ATPase. Furthermore,?ebselen?may be neuroprotective due to its ability to neutralize free radicals upon?NMDA?receptor activation thus, reducing lipoperoxidation mediated by?glutamate-induced excitotoxicity.
